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Estrogen Receptor alpha antibody [6F11] (ready-to-use)

Anti-Estrogen Receptor alpha antibody [6F11] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX73808

Cat. No. GTX73808

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 6F11

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
5 ml ($609)
See all Estrogen Receptor alpha products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P Assay dependent

Note :

IHC-P
Recommendations for antigen retrieval : EDTA buffer pH 8.0 at room temperature for 30 mins.
Not tested in other applications.

Calculated MW

66 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein corresponding to the full-length estrogen receptor molecule.

Purification

Unpurified

Conjugation

Unconjugated

RRID

AB_376058

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

estrogen receptor 1 , ER , ESR , ESRA , ESTRR , Era , NR3A1

Cellular Localization

Cytoplasm , Cell membrane , Cell membrane; Single-pass type I membrane protein , Golgi apparatus

Background

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

Database

Research Area

DATA IMAGES

Anti-Estrogen Receptor alpha antibody [6F11] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX73808

GTX73808 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX73808 Estrogen Receptor alpha antibody [6F11] (ready-to-use).

REFERENCE

Application Reference

Belcher SM et al. Endocrinology 2009; 150 (3) : 1112-21 Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma.
Application : IHC-P
Reactivity : Human

Clone Reference

Col?n-Caraballo M et al. Appl Immunohistochem Mol Morphol 2019; 27 (7):491-500 Human Endometriosis Tissue Microarray Reveals Site-specific Expression of Estrogen Receptors, Progesterone Receptor, and Ki67.
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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 609