14-3-3 sigma antibody
|Applications||ICC/IF, IHC-P, IP, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||28 kDa (note)
|Positive Controls||A549 , 293T , A431 , HeLa , HepG2 , A375 , Neuro2A , GL261 , C8D30|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Product Description||Rabbit Polyclonal antibody to 14-3-3 sigma (stratifin)|
|Background||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. p53-regulated inhibitor of G2/M progression. |
|Synonyms||YWHAS antibody, SFN antibody, epithelial cell marker protein 1 antibody, 14-3-3 protein sigma antibody, 14-3-3 sigma antibody, stratifin antibody|
|Cellular Localization||Cytoplasm , Nucleus , Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human 14-3-3 sigma. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Pig, Chicken, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Pig (96%), Chicken (80%), Sheep (97%), Rhesus Monkey (99%), Bovine (97%)|