|Full Name||5-hydroxytryptamine (serotonin) receptor 2C|
|Product Description||Rabbit Polyclonal antibody to 5-HT2C receptor|
|Background||Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq]|
|Synonyms||5-HT2C antibody, 5-HTR2C antibody, HTR1C antibody, HTR2C antibody, serotonin 5-HT-2C receptor antibody, 5-hydroxytryptamine receptor 1C antibody, serotonin receptor 2C antibody, 5-hydroxytryptamine receptor 2C antibody, 5-HT-2C antibody, 5-HT-1C antibody, 5-HT1C antibody, 5-hydroxytryptamine (serotonin) receptor 2C antibody|
|Cellular Localization||Cell membrane |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human 5HT2C Receptor. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Dog (100%), Chimpanzee (100%)|