58K Golgi protein antibody, N-term
|Applications||IHC, IHC-P, WB|
|Application Note||A 55-60kDa band observed in Human Liver lysate (calculated MW of 58.9kDa according to NP_006648. Recommended concentration: 0.03-0.5µg/ml. In paraffin embedded Human Liver shows distinct staining of membranes and cytoplasm in a selection of hepatocytes. Recommended concentration, 3-5µg/ml. Variants (NP_006648.1; NP_996848.1) encode the same protein.|
|Positive Controls||The peptide used to product this antibody is available for purchase (Catalog Number:GTX19072-PEP).|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.|
|Full Name||formiminotransferase cyclodeaminase|
|Product Description||Goat polyclonal antibody to 58K Golgi protein|
|Background||58K protein antibodies are excellent for use as markers for the Golgi complex. The 58K protein has been identified as being FTCD, a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency; also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.|
|Synonyms||LCHC1, formiminotransferase cyclodeaminase, formimidoyltransferase cyclodeaminase, 58K Golgi protein(NTerm)/FTCD, FTCD|
|Cellular Localization||Cytoplasmic and Golgi Apparatus|
|Specificity||This antibody is specific for 58K Golgi protein(N-Term)/FTCD.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.