|Full Name||ATP-binding cassette, sub-family D (ALD), member 2|
|Product Description||Rabbit polyclonal antibody to ABCD2 (ATP-binding cassette, sub-family D (ALD), member 2)|
|Background||The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq]|
|Synonyms||ABC39 antibody, ALDL1 antibody, ALDR antibody, ALDRP antibody, hALDR antibody, ABCD2 antibody, adrenoleukodystrophy-related protein antibody, ATP-binding cassette sub-family D member 2 antibody, adrenoleukodystrophy-like 1 antibody, "ATP-binding cassette, sub-family D (ALD), member 2 antibody"|
|Cellular Localization||Peroxisome membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ABCD2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chicken|
|Predict Reactivity Note||Mouse (94%), Rat (92%), Chicken (85%)|