|Full Name||ATP-binding cassette, sub-family G (WHITE), member 2|
|Product Description||Rabbit Polyclonal antibody to ABCG2 (ATP-binding cassette, sub-family G (WHITE), member 2)|
|Background||The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. [provided by RefSeq]|
|Synonyms||ABC15 antibody, ABCP antibody, BCRP antibody, BCRP1 antibody, BMDP antibody, CD338 antibody, CDw338 antibody, EST157481 antibody, MGC102821 antibody, MRX antibody, MXR antibody, MXR1 antibody, ABCG2 antibody, ATP-binding cassette sub-family G member 2 antibody, mitoxantrone resistance-associated protein antibody, breast cancer resistance protein antibody, ATP-binding cassette transporter G2 antibody, placenta-specific ATP-binding cassette transporter antibody, multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2 antibody, placenta specific MDR protein antibody, mitoxantrone resistance protein antibody, ABC transporter antibody, ATP-binding cassette, sub-family G (WHITE), member 2 antibody|
|Cellular Localization||Cell membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ABCG2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Pig, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (82%), Dog (83%), Pig (86%), Sheep (86%), Rhesus Monkey (97%), Bovine (85%)|