|Full Name||tyrosine kinase, non-receptor, 2|
|Product Description||Rabbit Polyclonal antibody to ACK1 (tyrosine kinase, non-receptor, 2)|
|Background||This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]|
|Synonyms||ACK antibody, ACK1 antibody, FLJ44758 antibody, FLJ45547 antibody, p21cdc42Hs antibody, TNK2 antibody, tyrosine kinase non-receptor protein 2 antibody, activated CDC42 kinase 1 antibody, activated p21cdc42Hs kinase antibody, activated Cdc42-associated kinase 1 antibody, tyrosine kinase, non-receptor, 2 antibody|
|Cellular Localization||Cell membrane |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human ACK1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (96%), Bovine (96%)|