ACMSD antibody [N2C3]
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||38 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , Molt-4 , Raji , mouse brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||aminocarboxymuconate semialdehyde decarboxylase|
|Product Description||Rabbit Polyclonal antibody to ACMSD (aminocarboxymuconate semialdehyde decarboxylase)|
|Background||The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 18.104.22.168) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM]|
|Synonyms||ACMSD antibody, picolinate carboxylase antibody, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase antibody, aminocarboxymuconate semialdehyde decarboxylase antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ACMSD. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Bovine|
|Predict Reactivity Note||Rat (88%), Zebrafish (86%), Bovine (93%)|