|Full Name||activin A receptor, type IB|
|Product Description||Rabbit Polyclonal antibody to ACVR1B (activin A receptor, type IB)|
|Background||Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq]|
|Synonyms||ACTRIB antibody, ACVRLK4 antibody, ALK4 antibody, SKR2 antibody, ACVR1B antibody, serine/threonine-protein kinase receptor R2 antibody, activin receptor type-1B antibody, activin receptor-like kinase 4 antibody, "activin A receptor, type II-like kinase 4 antibody", "activin A receptor, type IB antibody"|
|Cellular Localization||Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ACVR1B. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Xenopus laevis, Pig, Rhesus Monkey|
|Predict Reactivity Note||Rat (100%), Xenopus laevis (97%), Pig (100%), Rhesus Monkey (100%)|