AChR alpha 4 antibody [N1C1]
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||70 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||cholinergic receptor, nicotinic, alpha 4|
|Product Description||Rabbit Polyclonal antibody to AChR alpha 4|
|Background||This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. [provided by RefSeq]|
|Synonyms||BFNC antibody, EBN antibody, EBN1 antibody, FLJ95812 antibody, NACHR antibody, NACHRA4 antibody, NACRA4 antibody, CHRNA4 antibody, neuronal nicotinic acetylcholine receptor alpha-4 subunit antibody, "cholinergic receptor, nicotinic, alpha polypeptide 4 antibody", neuronal acetylcholine receptor subunit alpha-4 antibody, "cholinergic receptor, nicotinic, alpha 4 antibody"|
|Cellular Localization||Cell junction , synapse , postsynaptic cell membrane , Cell membrane |
|Target||AChR alpha 4|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Nicotinic Acetylcholine Receptor alpha 4. The exact sequence is proprietary.|
|Species Reactivity||Human, Hamster|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chicken, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (97%), Rat (97%), Chicken (91%), Chimpanzee (100%), Bovine (97%)|