|Full Name||ADAM metallopeptidase domain 17|
|Product Description||Rabbit Polyclonal antibody to ADAM17 (ADAM metallopeptidase domain 17)|
|Background||This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq]|
|Synonyms||ADAM18 antibody, CD156B antibody, CSVP antibody, MGC71942 antibody, TACE antibody, ADAM17 antibody, TNF-alpha converting enzyme antibody, snake venom-like protease antibody, tumor necrosis factor, alpha, converting enzyme antibody, TNF-alpha convertase antibody, disintegrin and metalloproteinase domain-containing protein 17 antibody, ADAM metallopeptidase domain 18 antibody, ADAM metallopeptidase domain 17 antibody|
|Cellular Localization||Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human ADAM17. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Dog, Pig, Chicken|
|Predict Reactivity Note||Dog (92%), Pig (93%), Chicken (83%)|