|Full Name||ADAM metallopeptidase with thrombospondin type 1 motif, 4|
|Product Description||Rabbit polyclonal antibody to ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif, 4)|
|Background||This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq]|
|Synonyms||ADAMTS-2 antibody, ADAMTS-4 antibody, ADMP-1 antibody, KIAA0688 antibody, ADAMTS4 antibody, ADAM-TS4 antibody, "a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 antibody", A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody, aggrecanase-1 antibody, ADAM-TS 4 antibody, "ADAM metallopeptidase with thrombospondin type 1 motif, 4 antibody"|
|Cellular Localization||Secreted , extracellular space , extracellular matrix |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ADAMTS4. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Bovine|
|Predict Reactivity Note||Human (100%), Rat (94%), Bovine (94%)|