AIF antibody [N1N2], N-term
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||67 kDa (note)
|Positive Controls||293T , A431 , HeLa , HepG2 , A375|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||apoptosis-inducing factor, mitochondrion-associated, 1|
|Product Description||Rabbit Polyclonal antibody to AIF (apoptosis-inducing factor, mitochondrion-associated, 1)|
|Background||This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq]|
|Synonyms||AIF antibody, COXPD6 antibody, MGC111425 antibody, PDCD8 antibody, AIFM1 antibody, striatal apoptosis-inducing factor antibody, apoptosis-inducing factor 1, mitochondrial antibody, programmed cell death 8 (apoptosis-inducing factor) antibody, apoptosis-inducing factor, mitochondrion-associated, 1 antibody|
|Cellular Localization||Mitochondrion intermembrane space , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human AIF. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Pig (81%), Bovine (83%)|