|Full Name||autoimmune regulator|
|Product Description||Goat polyclonal antibody to AIRE (isoforms 1 + 2)|
|Background||Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. |
|Synonyms||autoimmune regulator (automimmune polyendocrinopathy candidiasis ectodermal dystrophy), autoimmune regulator AIRE, AIRE (isoforms1 + 2), autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy), PGA1, AIR, autoimmune regulator (APECED protein), AIRE1, APECED, APS1, APSI|
|Cellular Localization||Associated with tubular structures and in discrete nuclear dots resembling ND10 nuclear bodies. May shuttle between nucleus and cytoplasm. |
|Specificity||This antibody is specific for AIRE (isoforms 1 + 2).|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Bovine|