|Full Name||A kinase (PRKA) anchor protein 10|
|Product Description||Goat polyclonal antibody to AKAP10|
|Background||Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase. |
|Synonyms||DAKAP2, AKAP10, D-AKAP2, protein kinase A anchoring protein10, Akinase anchor protein10, A kinase (PRKA) anchor pro, MGC9414, dualspecificity Akinase anchoring protein 2, dualspecificity Akinase anchoring protein2, A-kinase anchor protein 10, Akinase anchor protein 10, dual-specificity A-kinase anchoring protein 2, protein kinase A anchoring protein 10, PRKA10, D AKAP2, A kinase anchor protein 10|
|Cellular Localization||Predominantly mitochondrial but also membrane associated and cytoplasmic. |
|Specificity||This antibody is specific for AKAP10.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Dog, Bovine|