|Applications||ELISA, ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||56 kDa (note)
|Positive Controls||GL261 , C8D30 , BCL-1 , Raw264.7 , HepG2 , HepG2 cytoplasm extract|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||aldehyde dehydrogenase 2 family (mitochondrial)|
|Product Description||Rabbit Polyclonal antibody to ALDH2 (aldehyde dehydrogenase 2 family (mitochondrial))|
|Background||This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. [provided by RefSeq]|
|Synonyms||ALDH-E2 antibody, ALDHI antibody, ALDM antibody, MGC1806 antibody, ALDH2 antibody, nucleus-encoded mitochondrial aldehyde dehydrogenase 2 antibody, liver mitochondrial ALDH antibody, aldehyde dehydrogenase, mitochondrial antibody, acetaldehyde dehydrogenase 2 antibody, ALDH class 2 antibody, aldehyde dehydrogenase 2 family (mitochondrial) antibody|
|Cellular Localization||Mitochondrion matrix |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ALDH2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Xenopus laevis, Pig, Bovine|
|Predict Reactivity Note||Rat (96%), Xenopus laevis (82%), Pig (94%), Bovine (94%)|