Full Name | protein kinase, AMP-activated, alpha 1 catalytic subunit |
Background | The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
Synonyms | AMPKa1 Antibody , PRKAA1 Antibody , AMPK Antibody , protein kinase, AMP-activated, alpha 1 catalytic subunit Antibody |
Specificity | Recognizes endogenous levels of AMPK alpha 1 (pS496) protein. |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human AMPK alpha 1 (pS496). The exact sequence is proprietary. |
Antigen Species | Human |
Species Reactivity | Human, Mouse, Rat |
Conjugation | Unconjugated |