AMPK alpha 2 antibody
|Applications||ICC/IF, IHC-P, IP, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||62 kDa (note)
|Positive Controls||293T , A431 , HeLa , HepG2 , NIH-3T3|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||protein kinase, AMP-activated, alpha 2 catalytic subunit|
|Product Description||Rabbit Polyclonal antibody to AMPK alpha 2 (protein kinase, AMP-activated, alpha 2 catalytic subunit)|
|Background||The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq]|
|Synonyms||AMPK antibody, AMPK2 antibody, PRKAA antibody, PRKAA2 antibody, AMPK-alpha-2 chain antibody, 5'-AMP-activated protein kinase, catalytic alpha-2 chain antibody, 5'-AMP-activated protein kinase catalytic subunit alpha-2 antibody, AMPK subunit alpha-2 antibody, protein kinase, AMP-activated, alpha 2 catalytic subunit antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human AMPK alpha 2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Pig, Chicken, Sheep, Bovine|
|Predict Reactivity Note||Pig (99%), Chicken (96%), Sheep (98%), Bovine (99%)|