|Full Name||protein kinase, AMP-activated, beta 1 non-catalytic subunit|
|Product Description||Rabbit Polyclonal antibody to AMPK beta 1 (protein kinase, AMP-activated, beta 1 non-catalytic subunit)|
|Background||The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq]|
|Synonyms||AMPK antibody, HAMPKb antibody, MGC17785 antibody, PRKAB1 antibody, AMPKb antibody, protein kinase, AMP-activated, noncatalytic, beta-1 antibody, AMPK beta -1 chain antibody, 5'-AMP-activated protein kinase beta-1 subunit antibody, AMPK beta 1 antibody, 5'-AMP-activated protein kinase subunit beta-1 antibody, AMP-activated protein kinase beta subunit antibody, AMPK subunit beta-1 antibody, protein kinase, AMP-activated, beta 1 non-catalytic subunit antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human AMPK beta 1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Pig, Chicken, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (97%), Rat (97%), Xenopus laevis (89%), Pig (97%), Chicken (95%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (96%)|