|Full Name||adenomatous polyposis coli|
|Product Description||Rabbit Polyclonal antibody to APC (adenomatous polyposis coli)|
|Background||This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq]|
|Synonyms||BTPS2 antibody, DP2 antibody, DP2.5 antibody, DP3 antibody, GS antibody, APC antibody, deleted in polyposis 2.5 antibody, "protein phosphatase 1, regulatory subunit 46 antibody", adenomatous polyposis coli protein antibody, adenomatosis polyposis coli tumor suppressor antibody, adenomatous polyposis coli antibody|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human APC. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Bovine|
|Predict Reactivity Note||Mouse (94%), Rat (94%), Pig (88%), Bovine (88%)|