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  • APP antibody [7B8]

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1 .GTX84876 APP antibody [7B8]

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APP antibody [7B8]


  • Host / ClonalityMouse Monoclonal
  • Clone Name7B8
  • ApplicationsFACS, ICC/IF, IHC-P, WB
  • Species reactivityHuman
Cat No: GTX84876
Package Price Qty
100 μlUSD 339.00
Add to cart
 
  • Anti-APP antibody [7B8] used in IHC (Formalin-fixed paraffin-embedded sections). GTX84876
  • Anti-APP antibody [7B8] used in IHC (Formalin-fixed paraffin-embedded sections). GTX84876
  • Anti-APP antibody [7B8] used in Western Blot (WB). GTX84876
  • Anti-APP antibody [7B8] used in Flow cytometry/FACS. GTX84876
  • Anti-APP antibody [7B8] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84876
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  • Datasheet
  • Application Information: APP antibody [7B8]

Catalog Number GTX84876
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Product Name APP antibody [7B8]
See all APP products
ApplicationsFACS, ICC/IF, IHC-P, WB
Application NoteRecommended Starting Dilutions:

WB 1:2000
IHC 1:50
ICC/IF 1:100
Flow 1:100
Optimal working dilutions should be determined experimentally by the end user.

Form SuppliedLiquid
PurificationProtein A/G purified

  • Specifications: APP antibody [7B8]

Full Nameamyloid beta (A4) precursor protein (APP), transcript variant 1
BackgroundFunctions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
SynonymsAPP, ABETA, CTFgamma, ABPP, AD1, APPI, CVAP, PN2, AAA
SpecificityGTX84876 is specific for human APP (NP_000475).
HostMouse
ClonalityMonoclonal
Clone Name7B8
IsotypeIgG1
ImmunogenFull length human recombinant protein of human APP (NP_000475) produced in HEK293T cell.
Antigen SpeciesHuman
Species ReactivityHuman
ConjugationUnconjugated

  • Storage Conditions: APP antibody [7B8]

Storage BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Storage InstructionFor short-term storage, store at 4°C or aliquot into working amounts and store at -20°C. For long-term storage, store at -70°C (aliquotted). Avoid repeated freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Cancer > Apoptosis > Nervous system > Neuron
  • Cell Biology > Apoptosis > Nervous system > Neuron
  • Cell Biology > Endocytosis
  • Disease Related > Alzheimer's disease
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APP antibody [7B8] validated data
  • Anti-APP antibody [7B8] used in IHC (Formalin-fixed paraffin-embedded sections). GTX84876
    • GTX84876 IHC-P Image
      Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-APP mouse monoclonal antibody. (GTX84876, Dilution 1:50)
      Top
  • Anti-APP antibody [7B8] used in IHC (Formalin-fixed paraffin-embedded sections). GTX84876
    • GTX84876 IHC-P Image
      Immunohistochemical staining of paraffin-embedded prostate tissue using anti-APP mouse monoclonal antibody. (GTX84876, Dilution 1:50)
      Top
  • Anti-APP antibody [7B8] used in Western Blot (WB). GTX84876
    • GTX84876 WB Image
      HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY APP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APP.
      Top
  • Anti-APP antibody [7B8] used in Flow cytometry/FACS. GTX84876
    • GTX84876 FACS Image
      HEK293T cells transfected with either pCMV6-ENTRY APP
      Top
  • Anti-APP antibody [7B8] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84876
    • GTX84876 ICC/IF Image
      Anti-APP mouse monoclonal antibody (GTX84876) immunofluorescent staining of COS7 cells transiently transfected with APP
      Top
  • Anti-APP antibody [7B8] used in IHC (Formalin-fixed paraffin-embedded sections). GTX84876
    • GTX84876 IHC-P Image
      Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-APP mouse monoclonal antibody. (GTX84876, Dilution 1:50)
      Top
  • Anti-APP antibody [7B8] used in IHC (Formalin-fixed paraffin-embedded sections). GTX84876
    • GTX84876 IHC-P Image
      Immunohistochemical staining of paraffin-embedded prostate tissue using anti-APP mouse monoclonal antibody. (GTX84876, Dilution 1:50)
      Top
  • Anti-APP antibody [7B8] used in Western Blot (WB). GTX84876
    • GTX84876 WB Image
      HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY APP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APP.
      Top
  • Anti-APP antibody [7B8] used in Flow cytometry/FACS. GTX84876
    • GTX84876 FACS Image
      HEK293T cells transfected with either pCMV6-ENTRY APP
      Top
  • Anti-APP antibody [7B8] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84876
    • GTX84876 ICC/IF Image
      Anti-APP mouse monoclonal antibody (GTX84876) immunofluorescent staining of COS7 cells transiently transfected with APP
      Top
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