|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||87 kDa (note)
|Positive Controls||U87-MG , SK-N-SH , IMR32 , SK-N-AS , human cerebrospinal fluid , mouse brain , rat brian|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||amyloid beta (A4) precursor protein|
|Product Description||Rabbit polyclonal antibody to APP|
|Background||This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, APPI antibody, CTFgamma antibody, CVAP antibody, PN2 antibody, APP antibody, alzheimer disease amyloid protein antibody, beta-amyloid peptide antibody, amyloid beta A4 protein antibody, peptidase nexin-II antibody, protease nexin-II antibody, cerebral vascular amyloid peptide antibody, preA4 antibody, amyloid beta (A4) precursor protein antibody, beta Amyloid antibody|
|Cellular Localization||Membrane , Membrane , clathrin-coated pit |
|Target||amyloid beta A4|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human APP. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Pig, Chicken, Chimpanzee, Bovine|
|Predict Reactivity Note||Pig (81%), Chicken (80%), Chimpanzee (100%), Bovine (83%)|