|Full Name||adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1|
|Product Description||Rabbit Polyclonal antibody to APPL1 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1)|
|Background||The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq]|
|Synonyms||APPL antibody, DIP13alpha antibody, APPL1 antibody, DCC-interacting protein 13-alpha antibody, "adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 antibody", "adapter protein containing PH domain, PTB domain and leucine zipper motif 1 antibody", AKT2 interactor antibody, signaling adaptor protein DIP13alpha antibody, dip13-alpha antibody, "adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 antibody"|
|Cellular Localization||Early endosome membrane , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human APPL1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Pig, Bovine|
|Predict Reactivity Note||Xenopus laevis (89%), Pig (97%), Bovine (98%)|