|Full Name||Rho guanine nucleotide exchange factor (GEF) 3|
|Product Description||Rabbit Polyclonal antibody to ARHGEF3 (Rho guanine nucleotide exchange factor (GEF) 3)|
|Background||Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||DKFZp434F2429 antibody, FLJ98126 antibody, GEF3 antibody, MGC118905 antibody, STA3 antibody, XPLN antibody, ARHGEF3 antibody, "exchange factor found in platelets and leukemic and neuronal tissues, XPLN antibody", rho guanine nucleotide exchange factor 3 antibody, 59.8 kDA protein antibody, RhoGEF protein antibody, Rho guanine nucleotide exchange factor (GEF) 3 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ARHGEF3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Chicken|
|Predict Reactivity Note||Mouse (100%), Rat (99%), Zebrafish (87%), Chicken (93%)|