|Full Name||aryl-hydrocarbon receptor nuclear translocator 2|
|Product Description||Rabbit polyclonal antibody to ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2)|
|Background||This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq]|
|Synonyms||KIAA0307 antibody, bHLHe1 antibody, ARNT2 antibody, aryl hydrocarbon receptor nuclear translocator 2 antibody, class E basic helix-loop-helix protein 1 antibody, ARNT protein 2 antibody, aryl-hydrocarbon receptor nuclear translocator 2 antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ARNT2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Zebrafish, Xenopus laevis, Sheep, Bovine|
|Predict Reactivity Note||Human (100%), Rat (98%), Zebrafish (88%), Xenopus laevis (91%), Sheep (98%), Bovine (98%)|