|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||101 kDa (note)
|Positive Controls||293T , A431 , Jurkat , Raji , HeLa , HepG2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||serrate RNA effector molecule homolog (Arabidopsis)|
|Product Description||Rabbit Polyclonal antibody to ARS2 (serrate RNA effector molecule homolog (Arabidopsis))|
|Background||Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and RNASEN, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. |
|Synonyms||ARS2 antibody, ASR2 antibody, MGC126427 antibody, serrate antibody, SRRT antibody, arsenate resistance protein 2 antibody, arsenite resistance protein antibody, serrate RNA effector molecule homolog antibody, arsenate resistance protein ARS2 antibody, arsenite-resistance protein 2 antibody, serrate RNA effector molecule homolog (Arabidopsis) antibody|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human ARS2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Xenopus Tropicalis, Bovine|
|Predict Reactivity Note||Mouse (97%), Xenopus Tropicalis (80%), Bovine (97%)|