|Full Name||mitogen-activated protein kinase kinase kinase 5|
|Product Description||Rabbit Polyclonal antibody to ASK1 (mitogen-activated protein kinase kinase kinase 5)|
|Background||Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq]|
|Synonyms||ASK1 antibody, MAPKKK5 antibody, MEKK5 antibody, MAP3K5 antibody, mitogen-activated protein kinase kinase kinase 5 antibody, apoptosis signal regulating kinase 1 antibody, MAP/ERK kinase kinase 5 antibody, MEK kinase 5 antibody, MAPK/ERK kinase kinase 5 antibody, ASK-1 antibody, MEKK 5 antibody, apoptosis signal-regulating kinase 1 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human ASK1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (91%), Bovine (93%)|