|Full Name||additional sex combs like 1 (Drosophila)|
|Product Description||Rabbit Polyclonal antibody to ASXL1 (additional sex combs like 1 (Drosophila))|
|Background||This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq]|
|Synonyms||KIAA0978 antibody, MGC117280 antibody, MGC71111 antibody, ASXL1 antibody, putative Polycomb group protein ASXL1 antibody, additional sex combs-like protein 1 antibody, additional sex combs like 1 (Drosophila) antibody|
|Specificity||Knockdown/Knockout validation was supported by references (PMID:26385183)|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human ASXL1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (93%)|