ATP citrate lyase antibody [C2C3], C-term
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||121 kDa (note)
|Positive Controls||HeLa , Raji , mouse brain , PC-12 , Rat-2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||ATP citrate lyase|
|Product Description||Rabbit Polyclonal antibody to ATP citrate lyase (ATP citrate lyase)|
|Background||ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]|
|Synonyms||ACL antibody, ATPCL antibody, CLATP antibody, ACLY antibody, ATP citrate synthase antibody, ATP-citrate (pro-S-)-lyase antibody, ATP-citrate synthase antibody, citrate cleavage enzyme antibody, ATP citrate lyase antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human ATP citrate lyase. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Pig, Chicken, Sheep, Bovine|
|Predict Reactivity Note||Xenopus laevis (91%), Pig (98%), Chicken (95%), Sheep (99%), Bovine (99%)|