|Full Name||ATPase, Cu++ transporting, alpha polypeptide|
|Product Description||Rabbit Polyclonal antibody to ATP7A (ATPase, Cu++ transporting, alpha polypeptide)|
|Background||This gene encodes a transmembrane protein that functions in copper transport across membranes. The protein localizes to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. The protein relocalizes to the plasma membrane under conditions of elevated extracellular copper and functions in the efflux of copper from cells. Mutations in this gene result in Menkes disease, X-linked cutis laxa, and occipital horn syndrome. [provided by RefSeq]|
|Synonyms||DSMAX antibody, FLJ17790 antibody, MK antibody, MNK antibody, SMAX3 antibody, ATP7A antibody, Menkes disease-associated protein antibody, Cu++-transporting P-type ATPase antibody, copper pump 1 antibody, copper-transporting ATPase 1 antibody, "ATPase, Cu++ transporting, alpha polypeptide antibody"|
|Cellular Localization||Golgi apparatus , trans-Golgi network membrane , Cell membrane , Isoform 3: Cytoplasm , cytosol , Isoform 5: Endoplasmic reticulum |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human ATP7A. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (82%), Bovine (87%)|