ATR antibody [2B5]
|Applications||ICC/IF, IP, WB, Functional Assay|
Not tested in other applications.
| Immunocytochemistry/ Immunofluorescence||Assay-dependent dilution
| Immunoprecipitation||Assay-dependent dilution
| Functional Assay||Assay-dependent dilution
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||317 kDa (note)
|Positive Controls||Raji , Raji nuclear extract|
(Please refer to the vial label for the specific concentration)|
|Purification||Protein G purified|
|Full Name||ataxia telangiectasia and Rad3 related|
|Product Description||Mouse monoclonal [2B5] to ATR|
|Background||Ataxia Telangiectasia Mutated (ATM) and Rad3-related (ATR) protein is a member of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has a predicted molecular mass of approximately 301 kDa, and it has been shown to be involved in cellular responses to DNA damage. Specifically, it plays a role in checkpoint activation in response to either the presence of stalled replication forks, or by the presence of lesions caused by UV light. Inactivation of ATR is an embryonic lethal event in mice.|
|Synonyms||SCKL1, Q13535, ATR, 210600, MEC1, FRP1, SCKL, 545|
|Immunogen||Recombinant fragment, corresponding to amino acids 710-1100 of Human ATR.|