|Applications||ICC/IF, IHC-P, IP, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||301 kDa (note)
|Positive Controls||293T , A431 , HeLa , HepG2 , Raji , Raji NE|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||ataxia telangiectasia and Rad3 related|
|Product Description||Rabbit Polyclonal antibody to ATR (ataxia telangiectasia and Rad3 related)|
|Background||The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq]|
|Synonyms||FRP1 antibody, MEC1 antibody, SCKL antibody, SCKL1 antibody, ATR antibody, FRAP-related protein 1 antibody, serine/threonine-protein kinase ATR antibody, ataxia telangiectasia and Rad3-related protein antibody, Rad3 related protein antibody, FRAP-related protein-1 antibody, MEC1, mitosis entry checkpoint 1, homolog antibody, protein kinase ATR antibody, ataxia telangiectasia and Rad3 related antibody|
|Cellular Localization||Nucleus |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human ATR. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|