|Full Name||ataxin 10|
|Product Description||Rabbit Polyclonal antibody to ATXN10 (ataxin 10)|
|Background||The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and a varying degree of signs from other components of the nervous system. A commonly accepted clinical classification (Harding, 1993) divides ADCAs into 3 different groups based on the presence or absence of associated symptoms such as brainstem signs or retinopathy. The presence of pyramidal and extrapyramidal symptoms and ophthalmoplegia makes the diagnosis of ADCA I, the presence of retinopathy points to ADCA II, and the absence of associated signs to ADCA III. Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes.[supplied by OMIM]|
|Synonyms||E46L antibody, FLJ37990 antibody, HUMEEP antibody, SCA10 antibody, ATXN10 antibody, spinocerebellar ataxia type 10 protein antibody, brain protein E46 homolog antibody, ataxin-10 antibody, ataxin 10 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ATXN10. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (82%), Rat (85%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (87%)|