|Full Name||heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)|
|Product Description||Rabbit Polyclonal antibody to AUF1 (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa))|
|Background||This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq]|
|Synonyms||AUF1 antibody, AUF1A antibody, HNRPD antibody, P37 antibody, hnRNPD0 antibody, HNRNPD antibody, "ARE-binding protein AUFI, type A antibody", hnRNP D0 antibody, heterogeneous nuclear ribonucleoprotein D0 antibody, "heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) antibody"|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human AUF1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Chicken, Rhesus Monkey|
|Predict Reactivity Note||Rat (98%), Chicken (98%), Rhesus Monkey (100%)|