|Full Name||axin 1|
|Product Description||Rabbit Polyclonal antibody to AXIN1 (axin 1)|
|Background||This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]|
|Synonyms||AXIN antibody, MGC52315 antibody, AXIN1 antibody, axin-1 antibody, axis inhibitor 1 antibody, axis inhibition protein 1 antibody, "fused, mouse, homolog of antibody", "protein phosphatase 1, regulatory subunit 49 antibody", axin 1 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human AXIN1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Chicken, Bovine|
|Predict Reactivity Note||Xenopus laevis (80%), Chicken (84%), Bovine (94%)|