|Full Name||aconitase 1, soluble|
|Product Description||Rabbit Polyclonal antibody to Aconitase 1 (aconitase 1, soluble)|
|Background|| Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. [provided by RefSeq]|
|Synonyms||aconitase 1, soluble Antibody, ACONS Antibody, IRP1 Antibody, ACO1 Antibody, IREBP1 Antibody, IREBP Antibody, IREB1 Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Aconitase 1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rabbit, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (87%), Rat (86%), Rabbit (90%), Rhesus Monkey (99%), Bovine (89%)|