|Full Name||aconitase 1, soluble|
|Product Description||Rabbit Polyclonal antibody to Aconitase 1 (aconitase 1, soluble)|
|Background|| Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. [provided by RefSeq]|
|Synonyms||ACONS antibody, IREB1 antibody, IREBP antibody, IREBP1 antibody, IRP1 antibody, ACO1 antibody, citrate hydro-lyase antibody, iron regulatory protein 1 antibody, iron-responsive element-binding protein 1 antibody, iron-responsive element binding protein 1 antibody, aconitate hydratase antibody, cytoplasmic aconitate hydratase antibody, IRE-BP 1 antibody, ferritin repressor protein antibody, "aconitase 1, soluble antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Aconitase 1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Rabbit, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (93%), Rat (93%), Zebrafish (81%), Xenopus laevis (85%), Rabbit (94%), Chicken (85%), Rhesus Monkey (99%), Bovine (94%)|