|Full Name||activin A receptor, type I|
|Product Description||Rabbit Polyclonal antibody to Activin A Receptor type I (activin A receptor, type I)|
|Background||Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq]|
|Synonyms||ACTRI antibody, ACVR1A antibody, ACVRLK2 antibody, ALK2 antibody, FOP antibody, SKR1 antibody, TSRI antibody, ACVR1 antibody, serine/threonine-protein kinase receptor R1 antibody, activin receptor type I antibody, TGF-B superfamily receptor type I antibody, activin receptor-like kinase 2 antibody, hydroxyalkyl-protein kinase antibody, activin A receptor, type II-like kinase 2 antibody, activin receptor type-1 antibody, activin A receptor, type I antibody|
|Cellular Localization||Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Activin A Receptor type I. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Xenopus laevis, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (99%), Xenopus laevis (93%), Rhesus Monkey (100%), Bovine (100%)|