|Full Name||activin A receptor, type IIA|
|Product Description||Rabbit Polyclonal antibody to Activin A Receptor type IIA (activin A receptor, type IIA)|
|Background||This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq]|
|Synonyms||ACTRII antibody, ACVR2 antibody, ACVR2A antibody, activin receptor type-2A antibody, "activin A receptor, type IIA antibody"|
|Cellular Localization||Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Activin A Receptor type IIA. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Pig, Chicken, Sheep, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Xenopus laevis (94%), Pig (99%), Chicken (96%), Sheep (98%), Bovine (100%)|