|Full Name||alkaline phosphatase, liver/bone/kidney|
|Product Description||Rabbit polyclonal antibody to alkaline phosphatase (liver/bone/kidney) (alkaline phosphatase, liver/bone/kidney)|
|Background||There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq]|
|Synonyms||AP-TNAP antibody, APTNAP antibody, FLJ40094 antibody, FLJ93059 antibody, HOPS antibody, MGC161443 antibody, MGC167935 antibody, TNAP antibody, TNSALP antibody, ALPL antibody, alkaline phosphomonoesterase antibody, liver/bone/kidney-type alkaline phosphatase antibody, "alkaline phosphatase, tissue-nonspecific isozyme antibody", alkaline phosphatase liver/bone/kidney isozyme antibody, tissue-nonspecific ALP antibody, glycerophosphatase antibody, "alkaline phosphatase, liver/bone/kidney antibody"|
|Cellular Localization||Cell membrane; Lipid-anchor , GPI-anchor |
|Target||alkaline phosphatase (liver/bone/kidney)|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Alkaline Phosphatase (Tissue Non-Specific). The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Sheep|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Cat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (91%), Dog (89%), Cat (90%), Rhesus Monkey (97%), Bovine (89%)|