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1 .GTX48228-PRO Apolipoprotein A1 Recombinant Protein

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Apolipoprotein A1 Recombinant Protein


  • ApplicationsELISA, WB
Cat No: GTX48228-PRO
Package Price Qty
100 μgUSD 319.00
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  • Application Information: Apolipoprotein A1 Recombinant Protein

Catalog Number GTX48228-PRO
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Product Name Apolipoprotein A1 Recombinant Protein
See all Apolipoprotein A1 products
Full Nameapolipoprotein A-I
SynonymsApoA I, Apolipoprotein A I, ApoAI, Apolipoprotein AI
BackgroundApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high-density lipoprotein (HDL) particle. ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This apoA-I ability enables HDL to remove excess peripheral cholesterol and return it to the liver for recycling and excretion. This process, called reverse cholesterol transport, is though to inhibit atherogenesis. For this reason HDL is also known as the “good cholesterol.” The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I (called apoA-I Milano). The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases. Recombinant human ApoA-I is a 28.2 kDa protein of 244 amino acid residues.
SpeciesHuman
Region/SequenceMDEPPQSPWD RVKDLATVYV DVLKDSGRDY VSQFEGSALG KQLNLKLLDN WDSVTSTFSK LREQLGPVTQ EFWDNLEKET EGLRQEMSKD LEEVKAKVQP YLDDFQKKWQ EEMELYRQKV EPLRAELQEG ARQKLHELQE KLSPLGEEMR DRARAHVDAL RTHLAPYSDE LRQRLAARLE ALKENGGARL AEYHAKATEH LSTLSEKAKP ALEDLRQGLL PVLESFKVSF LSALEEYTKK LNTQ
Expression SystemE. coli
ApplicationsELISA, WB
ConjugationUnconjugated
Form SuppliedLyophilized powder
PurityGreater than 97% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
ConcentrationBatch dependent (Please refer to the vial label for the specific concentration)
Storage InstructionThe lyophilized recombinant protein is stable for at least 2 years from date of receipt at -20˚C. After reconstitution, it is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. Avoid multiple freeze-thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Disease Related > Alzheimer's disease
  • Disease Related > Atherosclerosis
  • Disease Related > Cardiovascular > Blood > Erythrocyte
  • Disease Related > Cardiovascular > Heart > Heart disease
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Apolipoprotein A1 Recombinant Protein validated data
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