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Catalog Number
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GTX42746
(
0
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Product Name
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Apolipoprotein E antibody [WUE-4] (Low endotoxin, azide free)
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| Applications | ELISA, WB, Functional Assay |
| Application Note |
| Suggested dilution | Reference |
| ELISA | 1/100-1/1,000* |
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| Western Blot (WB) | Assay-dependent dilution |
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| Functional Assay | Assay-dependent dilution |
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Western Blot (WB) : This antibody detects a major band of approximately 34-36kDa in human liver cell lysates.
Functional Assay : Mouse anti Human Apolipoprotein E antibody, clone WUE-4 has been shown to inhibit Apo-E mediated binding of lipoproteins to the apoB,E cell receptor (Krμl et al. 1998).
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
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| Form Supplied | Liquid |
| Concentration | 1.0
mg/ml
(Please refer to the vial label for the specific concentration) |
| Purification | Protein G purified |
| Purification Note | From tissue culture supernatant |
| Full Name | apolipoprotein E |
| Background | The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
| Synonyms | apolipoprotein E Antibody , AD2 Antibody , APOE Antibody , LPG Antibody , LDLCQ5 Antibody |
| Specificity | This antibody recognizes an epitope within amino acids 140-160 of human Apolipoprotein E, a major component of very low-density lipoproteins (VLDLs). |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | WUE-4 |
| Isotype | IgG1 |
| Immunogen | Purified ApoHDL fraction. |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse |
| Conjugation | Unconjugated |