|Full Name||beta-site APP-cleaving enzyme 1|
|Product Description||Rabbit Polyclonal antibody to BACE1 (beta-site APP-cleaving enzyme 1)|
|Background||Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]|
|Synonyms||ASP2 antibody, BACE antibody, FLJ90568 antibody, HSPC104 antibody, KIAA1149 antibody, BACE1 antibody, beta-site amyloid beta A4 precursor protein-cleaving enzyme antibody, beta-secretase 1 precursor variant 1 antibody, membrane-associated aspartic protease 2 antibody, aspartyl protease 2 antibody, transmembrane aspartic proteinase Asp2 antibody, APP beta-secretase antibody, beta-secretase 1 antibody, asp 2 antibody, beta-site APP cleaving enzyme 1 antibody, memapsin-2 antibody, beta-site APP-cleaving enzyme 1 antibody|
|Cellular Localization||Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human BACE1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Zebrafish, Pig, Rhesus Monkey, Bovine, Guinea pig|
|Predict Reactivity Note||Zebrafish (82%), Pig (100%), Rhesus Monkey (100%), Bovine (99%), Guinea pig (88%)|