|Full Name||BCL2-associated athanogene 3|
|Product Description||Rabbit Polyclonal antibody to BAG3 (BCL2-associated athanogene 3)|
|Background||BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq]|
|Synonyms||BAG-3 antibody, BIS antibody, CAIR-1 antibody, MGC104307 antibody, BAG3 antibody, docking protein CAIR-1 antibody, bcl-2-binding protein Bis antibody, BAG family molecular chaperone regulator 3 antibody, bcl-2-associated athanogene 3 antibody, BAG-family molecular chaperone regulator-3 antibody, BCL2-binding athanogene 3 antibody, BCL2-associated athanogene 3 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human BAG3. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (85%), Rhesus Monkey (97%), Bovine (83%)|