|Full Name||BAI1-associated protein 2|
|Product Description||Rabbit Polyclonal antibody to BAIAP2 (BAI1-associated protein 2)|
|Background||The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.|
|Synonyms||BAP2 antibody, FLAF3 antibody, IRSP53 antibody, BAIAP2 antibody, insulin receptor substrate p53/p58 antibody, insulin receptor substrate protein of 53 kDa antibody, IRSp53/58 antibody, IRS-58 antibody, brain-specific angiogenesis inhibitor 1-associated protein 2 antibody, fas ligand-associated factor 3 antibody, BAI1-associated protein 2 antibody|
|Cellular Localization||Cytoplasm , Membrane , Cell projection , filopodium , ruffle |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human BAIAP2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (98%), Bovine (98%)|