|Full Name||Bardet-Biedl syndrome 4|
|Product Description||Rabbit Polyclonal antibody to BBS4 (Bardet-Biedl syndrome 4)|
|Background||This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse. The similar phenotypes exhibited by mutations in BBS gene family members are likely due to the protein's shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene has sequence similarity to O-linked N-acetylglucosamine (O-GlcNAc) transferases in plants and archaebacteria and in human forms a multi-protein "BBSome" complex with six other BBS proteins. Alternative splice variants have been described but their predicted protein products have not been experimentally verified.|
|Synonyms||Bardet-Biedl syndrome 4 Antibody|
|Cellular Localization||Centrosome , Cytoplasm , cytoskeleton , Cell projection , cilium membrane |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human BBS4. The exact sequence is proprietary.|
|Species Reactivity||Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Pig, Chimpanzee, Bovine|
|Predict Reactivity Note||Human (100%), Pig (92%), Chimpanzee (98%), Bovine (91%)|