|Full Name||branched chain keto acid dehydrogenase E1, alpha polypeptide|
|Product Description||Rabbit Polyclonal antibody to BCKDHA (branched chain keto acid dehydrogenase E1, alpha polypeptide)|
|Background||The BCKDHA gene encodes the E1-alpha subunit of the branched-chain alpha-keto acid (BCAA) dehydrogenase complex (BCKD; EC 126.96.36.199), an inner-mitochondrial enzyme complex that catalyzes the oxidative decarboxylation of the branched-chain alpha-ketoacids derived from isoleucine, leucine, and valine. This reaction is the second major step in the catabolism of the branched-chain amino acids (Wynn et al., 1998 [PubMed 9582350]). The BCKD complex consists of 3 catalytic components: a heterotetrameric (alpha2-beta2) branched-chain alpha-keto acid decarboxylase (E1), a homo-24-meric dihydrolipoyl transacylase (E2; MIM 248610), and a homodimeric dihydrolipoamide dehydrogenase (E3; MIM 238331). E1 is a thiamine pyrophosphate (TPP)-dependent enzyme. The reaction is irreversible and constitutes the first committed step in BCAA oxidation. The BCKDHB gene (MIM 248611) encodes the beta subunit of E1. The complex also contains 2 regulatory enzymes, a kinase and a phosphorylase.[supplied by OMIM]|
|Synonyms||BCKDE1A antibody, FLJ45695 antibody, MSU antibody, MSUD1 antibody, OVD1A antibody, BCKDHA antibody, 2-oxoisovalerate dehydrogenase (lipoamide) antibody, BCKDH E1-alpha antibody, "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial antibody", branched-chain alpha-keto acid dehydrogenase E1 component alpha chain antibody, "branched chain keto acid dehydrogenase E1, alpha polypeptide antibody"|
|Cellular Localization||Mitochondrion matrix |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human BCKDHA. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Sheep, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (95%), Rat (95%), Pig (94%), Sheep (95%), Chimpanzee (98%), Bovine (94%)|