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Catalog Number
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GTX112744
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0
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Product Name
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BCL10 antibody
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| Applications | ICC/IF, IHC-P, IP, WB |
| Application Note |
| Suggested dilution | Reference |
| Immunocytochemistry/ Immunofluorescence | 1:100-1:1000* |
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| IHC (Formalin-fixed paraffin-embedded sections) | 1:100-1:1000* |
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| Immunoprecipitation | 1:100-1:500* |
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| Western blot | 1:500-1:3000* |
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Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
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| Predicted Target Size | 26 kDa (note)
 (2)
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| Positive Controls | HeLa , Raji , Neuro2A , GL261 , C8D30 |
| Form Supplied | Liquid |
| Concentration | 1
mg/ml
(Please refer to the vial label for the specific concentration) |
| Purification | Purified by antigen-affinity chromatography. |
| Full Name | B-cell CLL/lymphoma 10 |
| Product Description | Rabbit Polyclonal antibody to BCL10 (B-cell CLL/lymphoma 10) |
| Background | This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq] |
| Synonyms | CARMEN antibody, CIPER antibody, CLAP antibody, c-E10 antibody, mE10 antibody, BCL10 antibody, B-cell lymphoma/leukemia 10 antibody, cellular-E10 antibody, cCARMEN antibody, CARD containing molecule enhancing NF-kB antibody, hCLAP antibody, CED-3/ICH-1 prodomain homologous E10-like regulator antibody, mammalian CARD-containing adapter molecule E10 antibody, CARD-containing apoptotic signaling protein antibody, CARD-containing proapoptotic protein antibody, caspase-recruiting domain-containing protein antibody, cellular homolog of vCARMEN antibody, CARD-containing molecule enhancing NF-kappa-B antibody, B-cell CLL/lymphoma 10 antibody |
| Cellular Localization | Cytoplasm , perinuclear region |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human BCL10. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Rat, Pig, Rhesus Monkey, Bovine |
| Predict Reactivity Note | Rat (92%), Pig (92%), Rhesus Monkey (99%), Bovine (95%) |
| Conjugation | Unconjugated |