BCL10 antibody [N1C3]
|Applications||IHC-P, IP, WB, ChIP assay|
Not tested in other applications.
| ChIP assay||Assay-dependent dilution
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||26 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji , NIH-3T3|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||B-cell CLL/lymphoma 10|
|Product Description||Rabbit polyclonal antibody to BCL10 (B-cell CLL/lymphoma 10)|
|Background||This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq]|
|Synonyms||CARMEN antibody, CIPER antibody, CLAP antibody, c-E10 antibody, mE10 antibody, BCL10 antibody, B-cell lymphoma/leukemia 10 antibody, cellular-E10 antibody, cCARMEN antibody, CARD containing molecule enhancing NF-kB antibody, hCLAP antibody, CED-3/ICH-1 prodomain homologous E10-like regulator antibody, mammalian CARD-containing adapter molecule E10 antibody, CARD-containing apoptotic signaling protein antibody, CARD-containing proapoptotic protein antibody, caspase-recruiting domain-containing protein antibody, cellular homolog of vCARMEN antibody, CARD-containing molecule enhancing NF-kappa-B antibody, B-cell CLL/lymphoma 10 antibody|
|Cellular Localization||Cytoplasm , perinuclear region |
|Immunogen||Full length human BCL10 Recombinant protein.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (91%), Pig (92%), Rhesus Monkey (99%), Bovine (95%)|