|Full Name||bridging integrator 1|
|Product Description||Rabbit Polyclonal antibody to BIN1 (bridging integrator 1)|
|Background||This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq]|
|Synonyms||AMPH2 antibody, AMPHL antibody, DKFZp547F068 antibody, MGC10367 antibody, SH3P9 antibody, BIN1 antibody, box-dependent myc-interacting protein 1 antibody, amphiphysin-like protein antibody, amphiphysin II antibody, box dependant MYC interacting protein 1 antibody, myc box-dependent-interacting protein 1 antibody, bridging integrator 1 antibody|
|Cellular Localization||Isoform BIN1: Nucleus , Isoform IIA: Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human BIN1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Pig, Chicken, Bovine|
|Predict Reactivity Note||Mouse (93%), Rat (92%), Xenopus laevis (81%), Pig (94%), Chicken (84%), Bovine (93%)|